Calcium independent contraction induced by iodoacetic acid in isolated cerebral arteries.

@article{Toda1984CalciumIC,
  title={Calcium independent contraction induced by iodoacetic acid in isolated cerebral arteries.},
  author={Noboru Toda},
  journal={Stroke},
  year={1984},
  volume={15 3},
  pages={475-80}
}
In helically-cut strips of cerebral arteries isolated from dogs and monkeys, the addition of 1 mM iodoacetic acid (IAA) produced contractions during an early period (5 to 10 min) and also a prolonged exposure (50 to 70 min). The early contraction was abolished by exposure to Ca++-free media containing EGTA, and significantly attenuated by treatment with procaine or dantrolene. Verapamil, lidocaine, ATP and pyruvate did not inhibit the contraction. On the other hand, the late contraction was not… CONTINUE READING
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