Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid.

@article{Roderick2007CalciumIT,
  title={Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid.},
  author={H Llewelyn Roderick and Daniel R. Higazi and Ioannis Smyrnias and Catherine Fearnley and Dagmar Harzheim and Martin D Bootman},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 5},
  pages={957-61}
}
Ca(2+) increases in the heart control both contraction and transcription. To accommodate a short-term increased cardiovascular demand, neurohormonal modulators acting on the cardiac pacemaker and individual myocytes induce an increase in frequency and magnitude of myocyte contraction respectively. Prolonged, enhanced function results in hypertrophic growth of the heart, which is initially also associated with greater Ca(2+) signals and cardiac contraction. As a result of disease, however… CONTINUE READING