Calcium in suramin-induced rat sensory neuron toxicity in vitro.

  title={Calcium in suramin-induced rat sensory neuron toxicity in vitro.},
  author={Xiaojing Sun and Anthony J Windebank},
  journal={Brain research},
  volume={742 1-2},
Suramin is an experimental chemotherapeutic agent and a neurotoxin which causes a dose-dependent peripheral neuropathy in vivo and inhibits dorsal root ganglion (DRG) neurite outgrowth in vitro. The mechanism of suramin-induced cyto- and neurotoxicity remains unclear. Calcium is a key signal transducer in cellular responses to a variety of physiological and pathogenic stimuli. In the present study, we have determined the role of calcium in suramin-induced neurotoxicity in dorsal root ganglion… CONTINUE READING