Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

@inproceedings{Monai2016CalciumIR,
  title={Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain},
  author={Hiromu Monai and Masamichi Ohkura and Mika Tanaka and Yuki Oe and Ayumu Konno and Hirokazu Hirai and Katsuhiko Mikoshiba and Shigeyoshi Itohara and Junichi Nakai and Youichi Iwai and Hajime Hirase},
  booktitle={Nature communications},
  year={2016}
}
Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in… CONTINUE READING
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