Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.

@article{Ma2012CalciumHM,
  title={Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.},
  author={Zhongming Ma and Adam P Siebert and King-Ho Cheung and Robert J Lee and Brian Johnson and Akiva S. Cohen and Val{\'e}rie Vingtdeux and Philippe Marambaud and J. Kevin Foskett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 28},
  pages={E1963-71}
}
Extracellular Ca(2+) (Ca(2+)(o)) plays important roles in physiology. Changes of Ca(2+)(o) concentration ([Ca(2+)](o)) have been observed to modulate neuronal excitability in various physiological and pathophysiological settings, but the mechanisms by which neurons detect [Ca(2+)](o) are not fully understood. Calcium homeostasis modulator 1 (CALHM1) expression was shown to induce cation currents in cells and elevate cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) in response to removal of Ca(2… CONTINUE READING
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