Calcium homeostasis is dysregulated in parkinsonian patients with L-DOPA-induced dyskinesias.

@article{Blandini2009CalciumHI,
  title={Calcium homeostasis is dysregulated in parkinsonian patients with L-DOPA-induced dyskinesias.},
  author={Fabio Blandini and Eleonora Bazzini and Franca Marino and Federica Saporiti and M T Armentero and Claudio Pacchetti and Roberta Zangaglia and Emilia Martignoni and Sergio Lecchini and Giuseppe Nappi and Marco Cosentino},
  journal={Clinical neuropharmacology},
  year={2009},
  volume={32 3},
  pages={133-9}
}
Long-term treatment of Parkinson disease (PD) is frequently associated with l-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias (LIDs). L-DOPA-induced dyskinesias are likely due to changes in the signal transduction pathways, at the striatal level, related to pulsatile stimulation of dopamine receptors. We investigated whether markers of this phenomenon can also be detected peripherally. We analyzed mRNA expression for D5 (D1-like) and D3 (D2-like) receptors and levels of second… CONTINUE READING
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