Calcium homeostasis, selective vulnerability and Parkinson's disease

@article{Chan2009CalciumHS,
  title={Calcium homeostasis, selective vulnerability and Parkinson's disease},
  author={C Savio Chan and Tracy S. Gertler and D. James Surmeier},
  journal={Trends in Neurosciences},
  year={2009},
  volume={32},
  pages={249-256}
}
Parkinson's disease (PD) is a common neurodegenerative disorder of which the core motor symptoms are attributable to the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Recent work has revealed that the engagement of L-type Ca(2+) channels during autonomous pacemaking renders SNc DA neurons susceptible to mitochondrial toxins used to create animal models of PD, indicating that homeostatic Ca(2+) stress could be a determinant of their selective vulnerability… CONTINUE READING

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