Calcium homeostasis, selective vulnerability and Parkinson's disease

  title={Calcium homeostasis, selective vulnerability and Parkinson's disease},
  author={C Savio Chan and Tracy S. Gertler and D. James Surmeier},
  journal={Trends in Neurosciences},
Parkinson's disease (PD) is a common neurodegenerative disorder of which the core motor symptoms are attributable to the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Recent work has revealed that the engagement of L-type Ca(2+) channels during autonomous pacemaking renders SNc DA neurons susceptible to mitochondrial toxins used to create animal models of PD, indicating that homeostatic Ca(2+) stress could be a determinant of their selective vulnerability… CONTINUE READING


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Publications referenced by this paper.
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Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration

Kanaan, N.M
Eur. J. Neurosci • 2008

Glial reactions in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society • 2008

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