Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.

@article{Strling2005CalciumHA,
  title={Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.},
  author={Joachim St\orling and Sergei V. Zaitsev and Iouri L. Kapelioukh and Allan Ertman Karlsen and Nils Billestrup and P. -O. Berggren and Thomas Mandrup-Poulsen},
  journal={Endocrinology},
  year={2005},
  volume={146 7},
  pages={3026-36}
}
The c-jun N-terminal kinase (JNK) signaling pathway mediates IL-1beta-induced apoptosis in insulin-secreting cells, a mechanism relevant to the destruction of pancreatic beta-cells in type 1 and 2 diabetes. However, the mechanisms that contribute to IL-1beta activation of JNK in beta-cells are largely unknown. In this study, we investigated whether Ca(2+) plays a role for IL-1beta-induced JNK activation. In insulin-secreting rat INS-1 cells cultured in the presence of 11 mm glucose, combined… CONTINUE READING

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Interleukin-1 betaGene product is element in pathwayApoptosis
The c - jun N - terminal kinase ( JNK ) signaling pathway mediates IL-1beta - induced apoptosis in insulin - secreting cells , a mechanism relevant to the destruction of pancreatic beta - cells in type 1 and 2 diabetes .
Interleukin-1 betaGene product plays role in biological processApoptosis
The c - jun N - terminal kinase ( JNK ) signaling pathway mediates IL-1beta - induced apoptosis in insulin - secreting cells , a mechanism relevant to the destruction of pancreatic beta - cells in type 1 and 2 diabetes .
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