Calcium handling and sarcoplasmic-reticular protein functions during heart-failure transition in ventricular myocardium from rats with hypertension.

@article{Yoneda2001CalciumHA,
  title={Calcium handling and sarcoplasmic-reticular protein functions during heart-failure transition in ventricular myocardium from rats with hypertension.},
  author={Takashi Yoneda and Yasuki Kihara and Tomoko Ohkusa and Yoshitaka Iwanaga and Koichi Inagaki and Yukiko Takeuchi and Wataru Hayashida and Takashi Ueyama and Yuji Hisamatsu and M. Fujita and S Hatac and Masaji Matsuzaki and Shigetake Sasayama},
  journal={Life sciences},
  year={2001},
  volume={70 2},
  pages={
          143-57
        }
}
The objective of this study was to determine the primary event that occurs in Ca2+-regulatory sarcoplasmic-reticular (SR) proteins during subacute transition from concentric/mechanically-compensated left ventricular (LV) hypertrophy to eccentric/decompensated hypertrophy. Using Dahl salt-sensitive rats with hypertension, changes of myocardial contraction, intracellular Ca2+ transients, SR Ca2+ uptake, protein levels of SR Ca2+ ATPase (SERCA2), phospholamban, and calsequestrin (CSQ), and mRNA… CONTINUE READING

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