Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure.

@article{Yeh2008CalciumhandlingAU,
  title={Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure.},
  author={Yung-Hsin Yeh and Reza Wakili and Xiao-yan Qi and Denis Chartier and Peter Bokn{\'i}k and Stefan K{\"a}{\"a}b and Ursula Ravens and Pierre Coutu and Dobromir Dobrev and Stanley Nattel},
  journal={Circulation. Arrhythmia and electrophysiology},
  year={2008},
  volume={1 2},
  pages={93-102}
}
BACKGROUND Congestive heart failure (CHF) is a common cause of atrial fibrillation. Focal sources of unknown mechanism have been described in CHF-related atrial fibrillation. The authors hypothesized that abnormal calcium (Ca(2+)) handling contributes to the CHF-related atrial arrhythmogenic substrate. METHODS AND RESULTS CHF was induced in dogs by ventricular tachypacing (240 bpm x2 weeks). Cellular Ca(2+)-handling properties and expression/phosphorylation status of key Ca(2+) handling and… CONTINUE READING