Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

@inproceedings{Birnbaum2015CalciumFN,
  title={Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss},
  author={Jason Birnbaum and Jalandhar Tarun Bali and L Rajendran and Roger M. Nitsch and C Tackenberg},
  booktitle={Cell Death and Disease},
  year={2015}
}
Synaptic loss is one of the major features of Alzheimer’s disease (AD) and correlates with the degree of dementia. N-methyl-d-aspartate receptors (NMDARs) have been shown to mediate downstream effects of the β-amyloid peptide (Aβ) in AD models. NMDARs can trigger intracellular cascades via Ca2+ entry, however, also Ca2+-independent (metabotropic) functions of NMDARs have been described. We aimed to determine whether ionotropic or metabotropic NMDAR signaling is required for the induction of… CONTINUE READING
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References

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Showing 1-10 of 43 references

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.

Proceedings of the National Academy of Sciences of the United States of America • 2013
View 5 Excerpts
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Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms

L EJensen, G Bultynck, +3 authors HL Roderick
Front Mol Neurosci 2013; • 2013
View 1 Excerpt

Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression.

Proceedings of the National Academy of Sciences of the United States of America • 2013
View 1 Excerpt

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