Calcium dysregulation in amyotrophic lateral sclerosis.

  title={Calcium dysregulation in amyotrophic lateral sclerosis.},
  author={Julian Grosskreutz and Ludo Van Den Bosch and Bernhard U. Keller},
  journal={Cell calcium},
  volume={47 2},
In the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), motor neurons degenerate with signs of organelle fragmentation, free radical damage, mitochondrial Ca2+ overload, impaired axonal transport and accumulation of proteins in intracellular inclusion bodies. Subgroups of motor neurons of the brainstem and the spinal cord expressing low amounts of Ca2+ buffering proteins are particularly vulnerable. In ALS, chronic excitotoxicity mediated by Ca2+-permeable AMPA type… CONTINUE READING