Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.

@article{Smith2005CalciumDI,
  title={Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.},
  author={Ian F Smith and Kim N Green and Frank M Laferla},
  journal={Cell calcium},
  year={2005},
  volume={38 3-4},
  pages={427-37}
}
Alzheimer's disease is a progressive and irreversible neurodegenerative disorder that leads to cognitive, memory and behavioural impairments. Two decades of research have implicated disturbances of intracellular calcium homeostasis as playing a proximal pathological role in the neurodegeneration associated with Alzheimer's disease. A large preponderance of evidence has been gained from the use of a diverse range of cell lines. Whilst useful in understanding the principal mechanism of… CONTINUE READING
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