Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120.

@article{Haughey2002CalciumDA,
  title={Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120.},
  author={Norman J Haughey and Mark P. Mattson},
  journal={Journal of acquired immune deficiency syndromes},
  year={2002},
  volume={31 Suppl 2},
  pages={S55-61}
}
Patients with AIDS often develop cognitive and motor dysfunction that results from damage to synapses and death of neurons in brain regions such as the hippocampus and basal ganglia. This brain syndrome, called AIDS dementia or HIV encephalitis, is believed to result from the infection of one or more populations of mitotic brain cells with HIV-1, which then release viral proteins that are toxic to neurons. Two neurotoxic HIV-1 proteins have been identified, the viral coat protein gp120 and the… CONTINUE READING