Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.

@article{Demuro2005CalciumDA,
  title={Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.},
  author={Angelo Demuro and Erene W. Mina and Rakez Kayed and Saskia Charlotte Florence Milton and Ian Parker and Charles G. Glabe},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 17},
  pages={
          17294-300
        }
}
Increasing evidence suggests that amyloid peptides associated with a variety of degenerative diseases induce neurotoxicity in their intermediate oligomeric state, rather than as monomers or fibrils. To test this hypothesis and investigate the possible involvement of Ca2+ signaling disruptions in amyloid-induced cytotoxicity, we made homogeneous preparations of disease-related amyloids (Abeta, prion, islet amyloid polypeptide, polyglutamine, and lysozyme) in various aggregation states and tested… CONTINUE READING

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