Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study.

@article{Amini1999CalciumDU,
  title={Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study.},
  author={Behrang Amini and John W. Clark and Carmen C. Canavier},
  journal={Journal of neurophysiology},
  year={1999},
  volume={82 5},
  pages={2249-61}
}
A mathematical model of midbrain dopamine neurons has been developed to understand the mechanisms underlying two types of calcium-dependent firing patterns that these cells exhibit in vitro. The first is the regular, pacemaker-like firing exhibited in a slice preparation, and the second is a burst firing pattern sometimes exhibited in the presence of apamin. Because both types of oscillations are blocked by nifedipine, we have focused on the slow calcium dynamics underlying these firing modes… CONTINUE READING
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