Calcium dynamics and the mechanisms of atrioventricular junctional rhythm.

  title={Calcium dynamics and the mechanisms of atrioventricular junctional rhythm.},
  author={Daehyeok Kim and Tetsuji Shinohara and Boyoung Joung and Mitsunori Maruyama and Eue Keun Choi and Young Keun On and Seongwook Han and Michael C. Fishbein and Shien-Fong Lin and Peng-Sheng Chen},
  journal={Journal of the American College of Cardiology},
  volume={56 10},
OBJECTIVES The purpose of this study was to test the hypothesis that rhythmic spontaneous sarcoplasmic reticulum calcium (Ca) release (the "Ca clock") plays an important role in atrioventricular junction (AVJ) automaticity. BACKGROUND The AVJ is a primary backup pacemaker to the sinoatrial node. The mechanisms of acceleration of AVJ intrinsic rate during sympathetic stimulation are unclear. METHODS We simultaneously mapped transmembrane potential and intracellular Ca in Langendorff-perfused… CONTINUE READING
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