Calcium-dependent spike after-current induces burst firing in magnocellular neurosecretory cells

@article{Bourque1986CalciumdependentSA,
  title={Calcium-dependent spike after-current induces burst firing in magnocellular neurosecretory cells},
  author={Charles W. Bourque},
  journal={Neuroscience Letters},
  year={1986},
  volume={70},
  pages={204-209}
}
Magnocellular neurosecretory cells (MNCs) were impaled in perfused explants of rat hypothalamus. Application of a voltage clamp after 1-5 current-evoked spikes revealed a tetrodotoxin-resistant, but Cd2+-sensitive inward current. From a threshold near -85 mV, the amplitude of this current increased as post-spike commands were made to more positive potentials. Following its activation, the current-voltage relation of the cell displayed a region of negative resistance which crossed the spike… CONTINUE READING
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