Calcium-dependent regulation of cyclic GMP phosphodiesterase by a protein from frog retinal rods

@article{Kawamura1991CalciumdependentRO,
  title={Calcium-dependent regulation of cyclic GMP phosphodiesterase by a protein from frog retinal rods},
  author={Satoru Kawamura and Motohiko Murakami},
  journal={Nature},
  year={1991},
  volume={349},
  pages={420-423}
}
INvertebrate photoreceptors, light reduces cyclic GMP concentration and closes cGMP-activated channels to induce a hyperpolarizing response1. As Ca2+ can permeate the channels and the Na+ – Ca2+exchanger continuously extrudes Ca2+, closure of the channel results in a reduction of the inter-rod Ca2+ concentration2–4. This is believed to be one of the mechanisms of light-adaptation produced by activation of guanylate cyclase5–9. Effects of Ca2+on the cGMP phosphodiesterase (PDE) have been… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…