Calcium-dependent phospholipid scrambling by TMEM16F

@article{Suzuki2010CalciumdependentPS,
  title={Calcium-dependent phospholipid scrambling by TMEM16F},
  author={Jun Suzuki and Masato Umeda and Peter J. Sims and Shigekazu Nagata},
  journal={Nature},
  year={2010},
  volume={468},
  pages={834-838}
}
In all animal cells, phospholipids are asymmetrically distributed between the outer and inner leaflets of the plasma membrane. This asymmetrical phospholipid distribution is disrupted in various biological systems. For example, when blood platelets are activated, they expose phosphatidylserine (PtdSer) to trigger the clotting system. The PtdSer exposure is believed to be mediated by Ca2+-dependent phospholipid scramblases that transport phospholipids bidirectionally, but its molecular mechanism… CONTINUE READING
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