Calcium-dependent modulation of guanosine 3',5'-monophosphate in renal cortex. Possible relationship to calcium-dependent release of fatty acid.


The effects of Ca(2+) on cGMP accumulation in rat renal cortical slices were correlated with the effects on (14)C-fatty acid release in tissue prelabeled with (14)C arachidonate. Ca(2+) in the presence and absence of ionophore A23187 exerted parallel effects on the release of labeled arachidonate from slices and on slice cGMP content. Thus, Ca(2… (More)