Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide

@article{Zabel2002CalciumdependentMA,
  title={Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide},
  author={U. Zabel and C. Kleinschnitz and P. Oh and P. Nedvetsky and A. Smolenski and H. M{\"u}ller and Petra Kronich and P. Kugler and U. Walter and J. Schnitzer and H. Schmidt},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={307-311}
}
Nitric oxide (NO) is a ubiquitous, cell-permeable intercellular messenger. The current concept assumes that NO diffuses freely through the plasma membrane into the cytoplasm of a target cell, where it activates its cytosolic receptor enzyme, soluble guanylyl cyclase (sGC). Recent evidence, however, suggests that cellular membranes are not only the predominant site of calcium-dependent NO synthesis, but also the site of its distribution and binding. Here we extend this concept to NO signalling… Expand
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