Calcium-dependent membrane association of a flagellar calcium sensor does not require calcium binding.

@article{Maric2015CalciumdependentMA,
  title={Calcium-dependent membrane association of a flagellar calcium sensor does not require calcium binding.},
  author={Danijela Maric and C. L. Olson and Xianzhong Xu and James B Ames and David M. Engman},
  journal={Molecular and biochemical parasitology},
  year={2015},
  volume={201 1},
  pages={72-75}
}
Flagellar calcium-binding protein (FCaBP) is a dually acylated Ca(2+) sensor in the Trypanosoma cruzi flagellar membrane that undergoes a massive conformational change upon Ca(2+) binding. It is similar to neuronal Ca(2+) sensors, like recoverin, which regulate their binding partners through a calcium acyl switch mechanism. FCaBP is washed out of permeabilized cells with buffers containing EDTA, indicating Ca(2+)-dependent flagellar membrane association. We hypothesized that, like recoverin… CONTINUE READING

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