Calcium-dependent intestinal chloride secretion by Vibrio parahaemolyticus thermostable direct hemolysin in a rabbit model.

@article{Raimondi1995CalciumdependentIC,
  title={Calcium-dependent intestinal chloride secretion by Vibrio parahaemolyticus thermostable direct hemolysin in a rabbit model.},
  author={Francesco Raimondi and Joseph P.-Y. Kao and J. Kaper and Stefano Guandalini and Alessio Fasano},
  journal={Gastroenterology},
  year={1995},
  volume={109 2},
  pages={381-6}
}
BACKGROUND & AIMS Vibrio parahaemolyticus is a major agent of seafood gastroenteritis that induces intestinal secretion in the rabbit through its thermostable direct hemolysin. The aim of this study was to characterize the enterotoxicity of purified hemolysin in vitro. METHODS Rabbit ileum was mounted in Ussing chambers, and changes in potential difference and short-circuit current were monitored after addition of hemolysin. Intracellular calcium concentrations in the nontumoral rat crypt… CONTINUE READING
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