Calcium-dependent inactivation of the monosynaptic NMDA EPSCs in rat hippocampal neurons in culture.

@article{Medina1999CalciumdependentIO,
  title={Calcium-dependent inactivation of the monosynaptic NMDA EPSCs in rat hippocampal neurons in culture.},
  author={Igor Medina and Xavier Leinekugel and Yehezkel Ben-Ari},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 7},
  pages={2422-30}
}
The effects of increased dendritic calcium concentration ([Ca2+]i) induced by single action potentials on monosynaptic glutamatergic excitatory postsynaptic currents (EPSCs) were studied in cultured rat hippocampal neurons. To investigate the respective roles of pre- and postsynaptic elements in the depolarization-induced NMDAR inactivation, we have performed simultaneous paired whole-cell recordings from monosynaptically connected pre- and postsynaptic hippocampal neurons. We report that the… CONTINUE READING

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