Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells.

@article{NorgardSumnicht1993CalciumdependentHL,
  title={Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells.},
  author={K E Norgard-Sumnicht and Nissi M. Varki and Ajit Varki},
  journal={Science},
  year={1993},
  volume={261 5120},
  pages={480-3}
}
L-Selectin is a calcium-dependent mammalian lectin that mediates lymphocyte trafficking by recognizing sialylated ligands on high endothelial venules in lymph nodes. Although L-selectin probably mediates neutrophil extravasation into nonlymphoid tissues, no corresponding ligand has been characterized. Staining of cultured endothelial cells with an L-selectin chimera (LS-Rg) showed an internal pool of ligands. Metabolic labeling with sulfur-35-labeled sulfate revealed heparin lyase-sensitive… CONTINUE READING