Calcium-dependent binding of Myc to calmodulin

@inproceedings{Raffeiner2017CalciumdependentBO,
  title={Calcium-dependent binding of Myc to calmodulin},
  author={Philipp Raffeiner and Andrea Schraffl and Thomas C. Schwarz and Ruth R{\"o}ck and Karin Ledolter and Markus Hartl and Robert Konrat and Eduard Stefan and Klaus Bister},
  booktitle={Oncotarget},
  year={2017}
}
The bHLH-LZ (basic region/helix-loop-helix/leucine zipper) oncoprotein Myc and the bHLH-LZ protein Max form a binary transcription factor complex controlling fundamental cellular processes. Deregulated Myc expression leads to neoplastic transformation and is a hallmark of most human cancers. The dynamics of Myc transcription factor activity are post-translationally coordinated by defined protein-protein interactions. Here, we present evidence for a second messenger controlled physical… CONTINUE READING

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