Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.

@article{Parsaud2013CalciumdependentAP,
  title={Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.},
  author={Leon Parsaud and Lijun Li and Chang Hun Jung and Seungmee Park and Ner Mu Nar Saw and Sanghyun Park and Moo Yup Kim and Shuzo Sugita},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 32},
  pages={23050-63}
}
Calcium-dependent activator protein for secretion 1 (CAPS1) is a multidomain protein containing a Munc13 homology domain 1 (MHD1). Although CAPS1 and Munc13-1 play crucial roles in the priming stage of secretion, their functions are non-redundant. Similar to Munc13-1, CAPS1 binds to syntaxin-1, a key t-SNARE protein in neurosecretion. However, whether CAPS1 interacts with syntaxin-1 in a similar mode to Munc13-1 remains unclear. Here, using yeast two-hybrid assays followed by biochemical… CONTINUE READING
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