Calcium dependence of toxic cell death: a final common pathway.

  title={Calcium dependence of toxic cell death: a final common pathway.},
  author={Francis A X Schanne and Agnes B. Kane and Evelyn E. Young and John L. Farber},
  volume={206 4419},
Primary cultures of adult rat hepatocytes were treated in the presence or absence of extracellular calcium with ten different membrane-active toxins. In all cases more than half the cells were killed in 1 to 6 hours in the presence but not in the absence of extracellular calcium. An effect of calcium on the primary mechanism of membrane injury by any of the agents cannot be implicated. Viability, as determined by trypan blue exclusion correlated well with other indices of viability such as… CONTINUE READING

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