Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells.

@article{Brenowitz2003CalciumDO,
  title={Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells.},
  author={Stephan D. Brenowitz and Wade G Regehr},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 15},
  pages={
          6373-84
        }
}
Many types of neurons release endocannabinoids from their dendrites in response to elevation of intracellular calcium levels. Endocannabinoids then activate presynaptic cannabinoid receptors, thereby inhibiting neurotransmitter release for tens of seconds. A crucial step in understanding the physiological role of this retrograde signaling is to determine its sensitivity to elevations of postsynaptic calcium. Here we determine and compare the calcium dependence of endocannabinoid-mediated… CONTINUE READING

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