Calcium dependence of myosin light chain phosphorylation in smooth muscle cells.

  title={Calcium dependence of myosin light chain phosphorylation in smooth muscle cells.},
  author={Doris A Taylor and James T Stull},
  journal={The Journal of biological chemistry},
  volume={263 28},
Smooth muscle cells grown in culture may provide a model system for studying the Ca2+ dependence of myosin light chain phosphorylation. Tracheal smooth muscle cells in culture had 60% of the myosin content of tracheal tissue. Western analysis with appropriate antibodies demonstrated one 20-kDa light chain and the presence of a 150-kDa myosin light chain kinase in both tracheal smooth muscle tissue and cells. Moreover, tracheal cells contained 74% of the myosin light chain kinase activity… CONTINUE READING

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