Calcium cycling proteins and forcefrequency relationship in heart failure

@article{Hasenfuss2004CalciumCP,
  title={Calcium cycling proteins and forcefrequency relationship in heart failure},
  author={G. Hasenfuss and H. Reinecke and R. Studer and B. Pieske and M. Meyer and H. Drexler and H. Just},
  journal={Basic Research in Cardiology},
  year={2004},
  volume={91},
  pages={17-22}
}
  • G. Hasenfuss, H. Reinecke, +4 authors H. Just
  • Published 2004
  • Medicine
  • Basic Research in Cardiology
  • Myocardial function, intracellular calcium and levels of calcium cycling proteins were analyzed in failing and nonfailing human myocardium. Myocardial function was evaluated by the isometric force-frequency relation, and intracellular calcium was studied by aequorin light emission. When stimulation frequency was increased above 30 min−1, there was a continuous increase in isometric tension development in the nonfailing myocardium. In contrast, in failing myocardium, frequency potentiation of… CONTINUE READING
    Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium.
    73

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