Calcium cycling in heart failure: the arrhythmia connection.

Abstract

Ventricular tachycardia in nonischemic heart failure (HF) arises from a nonreentrant mechanism most likely due to delayed afterdepolarizations from activation of a transient inward current (I(ti)). We present data and a paradigm in which an up-regulated Na/Ca exchanger, residual beta-adrenergic responsiveness, and decreased inward rectifying K current (I(K1… (More)

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