Calcium current and charge movement of mammalian muscle: action of amyotrophic lateral sclerosis immunoglobulins.

@article{Delbono1991CalciumCA,
  title={Calcium current and charge movement of mammalian muscle: action of amyotrophic lateral sclerosis immunoglobulins.},
  author={Osvaldo Delbono and Jes{\'u}s Manuel Mart{\'i}nez Garc{\'i}a and Stanley H. Appel and Enrico Stefani},
  journal={The Journal of physiology},
  year={1991},
  volume={444},
  pages={
          723-42
        }
}
1. The Vaseline-gap voltage clamp technique was used to record dihydropyridine (DHP)-sensitive Ca2+ currents (ICa) and charge movement in single cut fibres from the rat extensor digitorum longus (EDL) muscle. Amyotrophic lateral sclerosis (ALS) immunoglobulin G (IgG) action on ICa and charge movement has been characterized. 2. ALS IgG reduced ICa amplitude. The peak ICa of EDL fibres (mean +/- S.E.M.) at 0 mV, expressed as amperes per membrane capacitance, was -4.79 +/- 0.029 A F-1, while after… CONTINUE READING
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