Calcium-containing crystals enhance receptor activator of nuclear factor κB ligand/macrophage colony-stimulating factor-mediated osteoclastogenesis via extracellular-signal-regulated kinase and p38 pathways.

@article{Chang2015CalciumcontainingCE,
  title={Calcium-containing crystals enhance receptor activator of nuclear factor κB ligand/macrophage colony-stimulating factor-mediated osteoclastogenesis via extracellular-signal-regulated kinase and p38 pathways.},
  author={Chi-Ching Chang and Yu-Hui Tsai and Yu Liu and Shyr-Yi Lin and Yu-Chih Liang},
  journal={Rheumatology},
  year={2015},
  volume={54 10},
  pages={
          1913-22
        }
}
OBJECTIVE Diseases associated with calcium-containing crystal deposition can lead to local bone erosion. We aimed to determine whether calcium-containing crystal-hydroxyapatite, β-tricalcium phosphate and CPPD enhanced osteoclastogenesis and to define underlying mechanisms of action. METHODS Osteoclastogenesis was studied by culturing murine RAW 264.7 osteoclast precursor cells with RANK ligand (RANKL)/ M-CSF and/or calcium-containing crystals, and observing the tartrate-resistant acid… CONTINUE READING

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Chi-Ching Chang
  • 2017