Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell.

@article{Langer1996CalciumCA,
  title={Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell.},
  author={Glenn A. Langer and Arthur Peskoff},
  journal={Biophysical journal},
  year={1996},
  volume={70 3},
  pages={1169-82}
}
We model the space between the junctional sarcoplasmic reticulum (JSR) membrane and the inner leaflet of the transverse tubular ("T") sarcolemmal (SL) membrane, the diadic cleft, with respect to calcium (Ca) concentration and movement. The model predicts the following: 1) Ca influx via the "L" channel increases [Ca] to 1 microM within a distance of 50 nm from the channel mouth in < 500 microseconds. This is sufficient to trigger Ca release from a domain of 9 "feet." 2) By contrast, "reverse" Na… CONTINUE READING

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