Calcium channels, neuromuscular synaptic transmission and neurological diseases.

@article{Urbano2008CalciumCN,
  title={Calcium channels, neuromuscular synaptic transmission and neurological diseases.},
  author={Francisco J Urbano and Mario Rafael Pagani and Osvaldo Daniel Uchitel},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={201-202},
  pages={136-44}
}
Voltage-dependent calcium channels are essential in neuronal signaling and synaptic transmission, and their functional alterations underlie numerous human disorders whether monogenic (e.g., ataxia, migraine, etc.) or autoimmune. We review recent work on Ca(V)2.1 or P/Q channelopathies, mostly using neuromuscular junction preparations, and focus specially on the functional hierarchy among the calcium channels recruited to mediate neurotransmitter release when Ca(V)2.1 channels are mutated or… CONTINUE READING