Calcium channel-independent action of fendiline in vascular smooth muscle

@article{Bayer1987CalciumCA,
  title={Calcium channel-independent action of fendiline in vascular smooth muscle},
  author={R. Bayer and E. Martini and F. Heckelmann},
  journal={Journal of Molecular and Cellular Cardiology},
  year={1987},
  volume={19}
}
Calcium channel antagonists part V: Second-generation agents
  • L. Opie
  • Medicine
  • Cardiovascular Drugs and Therapy
  • 2004
TLDR
From all these agents will be selected those that are longer-acting and provide higher vascular selectivity, including diphenylalkylamines, bepridil is of special interest. Expand
Sialic acid removal modulates the myocardial and vascular activity of calcium channel ligands.
TLDR
From the results obtained, it is concluded that sialic acid removal may modulate the action of calcium channel ligands through an inhibitory effect on transmembrane calcium fluxes and/or by decreasing the external calcium availability. Expand
Second-Generation Agents
TLDR
From all these agents will be selected those that are longer-acting and provide higher vascular selectivity, including diphenylalkylamines, diltiazem, and verapamil, the latter of which is of special interest. Expand
Basic mechanisms underlying prenylamine-induced 'torsade de pointes': differences between prenylamine and fendiline due to basic actions of the isomers.
TLDR
It seems possible that, under the condition of low heart rate, prenylamine (as reported for the calcium agonist Bay k 8644) increases the potential-dependent transmembrane calcium current and a reactivation of the calcium current induces early after-depolarizations. Expand