Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion.

@article{Ruggenenti1993CalciumCB,
  title={Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion.},
  author={Piero Ruggenenti and Norberto Perico and Lidia Mosconi and Flavio Gaspari and Ariela Benigni and C S Amuchastegui and I Bruzzi and Giuseppe Remuzzi},
  journal={Kidney international},
  year={1993},
  volume={43 3},
  pages={706-11}
}
Renal toxicity, possibly due to vasoconstriction and vascular injury, is the most relevant side-effect of chronic cyclosporine (CsA) therapy given to prevent graft rejection. In kidney transplant recipients each oral dose of CsA is invariably followed by a transient reduction in renal plasma flow (RPF) and glomerular filtration rate (GFR) that results from a form of acute reversible hypoperfusion. We sought to determine whether the Ca2+ channel blocker, lacidipine, prevented CsA-associated… CONTINUE READING
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