Calcium channel blockers in chronic heart failure. The risks of "physiologically rational" therapy.

@article{Packer1990CalciumCB,
  title={Calcium channel blockers in chronic heart failure. The risks of "physiologically rational" therapy.},
  author={Milton Packer},
  journal={Circulation},
  year={1990},
  volume={82 6},
  pages={
          2254-7
        }
}
oncerns have been raised about safety of calcium channel blockers in patients with heart failure since their introduction into cardiovascular medicine more than 25 years ago. By inhibiting the influx of calcium into myocardial cells, calcium channel-blocking drugs can depress contractility in both experimental systems and the clinical setting. The magnitude of this effect is enhanced when these drugs are combined with other negative inotropic agents (e.g., ,8-blockers) or when they are… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 23 REFERENCES

    Long - term clinical , hemodynamic , angiographic , and neurohumoral responses to vasodilation with felodipine in patients with chronic congestive heart failure

    • Dunselman PHJM, Kuntze CEE, +4 authors KI Lie
    • J Cardiovasc Pharmacol
    • 1990

    Combined beta-adrenergic and calcium-entry blockade in angina pectoris

    • M Packer
    • N Engl J Med
    • 1989

    Effect of diltiazem on long - term outcome in post - infarction patients with a history of hypertension ( abstract )

    • AJ Moss, M Rubison, +3 authors M Brown
    • Circulation
    • 1989

    Effects of diltiazem on occurrence of heart failure after myocardial infarction ( abstract )

    • RE Goldstein, S Boccuzzi, +4 authors M Rubison
    • Circulation
    • 1989

    Pathophysiological mechanisms underlying the adverse effects of calcium channel-blocking drugs in patients with chronic heart failure.

    Diltiazem reduces long - term cardiac event rate after non - Q wave infarction : Multicenter Diltiazem Post - Infarction Trial ( abstract )

    • WE Boden, RJ Krone, +3 authors AJ Moss
    • 1988

    Early treatment of unstable angina in the coronary care unit: a randomised, double blind, placebo controlled comparison of recurrent ischaemia in patients treated with nifedipine or metoprolol or both.

    The effect of diltiazem on mortality and reinfarction after myocardial infarction

    • JS Garrett, J Wikman-Coffelt, R Sievers, WE Finkbeiner, WW Parmley
    • N Engl J Med
    • 1988

    Baroreceptor function in congestive heart failure: effect on neurohumoral activation and regional vascular resistance.

    Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy.