• DOI:10.1161/01.CIR.82.6.2254
Corpus ID: 11255642

Calcium channel blockers in chronic heart failure. The risks of "physiologically rational" therapy.

@article{Packer1990CalciumCB,
  title={Calcium channel blockers in chronic heart failure. The risks of "physiologically rational" therapy.},
  author={M. Packer},
  journal={Circulation},
  year={1990},
  volume={82 6},
  pages={
          2254-7
        }
}

M. Packer

Published 1990

Medicine

Circulation

oncerns have been raised about safety of calcium channel blockers in patients with heart failure since their introduction into cardiovascular medicine more than 25 years ago. By inhibiting the influx of calcium into myocardial cells, calcium channel-blocking drugs can depress contractility in both experimental systems and the clinical setting. The magnitude of this effect is enhanced when these drugs are combined with other negative inotropic agents (e.g., ,8-blockers) or when they are… CONTINUE READING

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