Calcium channel blockers and Alzheimer's disease: potential relevance in treatment strategies of metabolic syndrome.
@article{Goodison2012CalciumCB, title={Calcium channel blockers and Alzheimer's disease: potential relevance in treatment strategies of metabolic syndrome.}, author={William V Goodison and V. Frisardi and P. Kehoe}, journal={Journal of Alzheimer's disease : JAD}, year={2012}, volume={30 Suppl 2}, pages={ S269-82 } }
Midlife hypertension is a risk factor for late onset Alzheimer's disease (AD) and it is one of the components of metabolic syndrome (MetS). Observational studies and some cardiovascular disease-related clinical trials suggest that antihypertensive treatment reduced the incidence and progression of AD. Calcium channel blockers (CCBs), one of the more commonly used treatments for hypertension, target voltage-gated calcium channels (VGCCs) which are found on neurons in the brain where calcium… CONTINUE READING
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