Corpus ID: 13250250

Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.

@article{Pragnell1994CalciumCB,
  title={Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.},
  author={M. Pragnell and M. De Waard and Y. Mori and T. Tanabe and T. Snutch and K. Campbell},
  journal={Nature},
  year={1994},
  volume={368 6466},
  pages={
          67-70
        }
}
  • M. Pragnell, M. De Waard, +3 authors K. Campbell
  • Published 1994
  • Medicine
  • Nature
  • The beta-subunit is an integral component of purified voltage-sensitive Ca2+ channels. Modulation of Ca2+ channel activity by the beta-subunit, which includes significant increases in transmembrane current and/or changes in kinetics, is observed on coexpression of six alpha 1-subunit genes with four beta-subunit genes in all alpha 1-beta combinations tested. Recent reports suggest that this regulation is not due to targeting of the alpha 1-subunit to the plasma membrane but is probably a result… CONTINUE READING
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