Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.

@article{Pragnell1994CalciumCB,
  title={Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.},
  author={Marion Pragnell and Michel De Waard and Yasuo Mori and Tsutomu Tanabe and Terry P. Snutch and Kevin P Campbell},
  journal={Nature},
  year={1994},
  volume={368 6466},
  pages={67-70}
}
The beta-subunit is an integral component of purified voltage-sensitive Ca2+ channels. Modulation of Ca2+ channel activity by the beta-subunit, which includes significant increases in transmembrane current and/or changes in kinetics, is observed on coexpression of six alpha 1-subunit genes with four beta-subunit genes in all alpha 1-beta combinations tested. Recent reports suggest that this regulation is not due to targeting of the alpha 1-subunit to the plasma membrane but is probably a result… CONTINUE READING

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