Calcium channel antagonists: part VI: Clinical pharmacokinetics of first and second-generation agents

@article{Opie1989CalciumCA,
  title={Calcium channel antagonists: part VI: Clinical pharmacokinetics of first and second-generation agents},
  author={Lionel Henry Opie},
  journal={Cardiovascular Drugs and Therapy},
  year={1989},
  volume={3},
  pages={482-497}
}
A survey of the pharmacokinetic properties of the three prototypical calcium antagonist agents shows that they have in common a very high rate of hepatic first-pass metabolism with, in the case of verapamil and diltiazem, the formation of an active metabolite that affects the dose during chronic therapy. Therefore, the major factor altering the pharmacokinetic properties and the dose of the drug required is the capacity of the liver to metabolize the drug, which in turn depends on the hepatic… CONTINUE READING

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