Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.

  title={Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.},
  author={Els{\'e} Marais and Norbert Klugbauer and Franz Hofmann},
  journal={Molecular pharmacology},
  volume={59 5},
High-voltage activated calcium channels are modulated by a series of auxiliary proteins, including those of the alpha(2)delta family. Until recently, only a single alpha(2)delta subunit was known, but two further members, alpha(2)delta-2 and -3, have since been identified. In this study, the structure of these two novel subunits has been characterized and binding of the antiepileptic drug gabapentin investigated. Using antibodies directed against the amino terminal portion of the proteins, the… CONTINUE READING

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