Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.

@article{Fang2002CalciumcalmodulindependentPK,
  title={Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.},
  author={Li Fang and Jing Wu and Qing Lin and William D. Willis},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 10},
  pages={4196-204}
}
Calcium/calmodulin-dependent protein kinase II (CaMK II) is found throughout the CNS. It regulates calcium signaling in synaptic transmission by phosphorylating various proteins, including neuronal membrane receptors and intracellular transcription factors. Inflammation or injuries to peripheral tissues cause long-lasting increases in the responses of central nociceptive neurons to innocuous and noxious stimuli. This change can occur independently of alterations in the responsiveness of primary… CONTINUE READING

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References

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Showing 1-10 of 75 references

Involvement of calcium/ calmodulin-dependent protein kinase II in central sensitization following intradermal injection of capsaicin in rats

  • J Wu, L Fang, Q Lin, WD Willis
  • XXXIX International Congress of Physiological…
  • 2001
Highly Influential
6 Excerpts

Mechanisms of central sensitization of nociceptive dorsal horn neurons. In: Spinal cord plasticity: alterations in reflex function (Patterson MM, Grau JW, eds), pp 127–161

  • WD Willis
  • 2001
Highly Influential
11 Excerpts

Central sensitization and plasticity following intense noxious stimulation

  • WD Willis
  • Basic and clinic aspect of chronic abdominal pain
  • 1993
Highly Influential
1 Excerpt

Central sensitization and plasticity following intense noxious stimulation. In: Basic and clinic aspect of chronic abdominal pain

  • WD Willis
  • (Mayer EA, Raybould HE,
  • 1993
Highly Influential
2 Excerpts

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