Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.

  title={Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma.},
  author={Yashwanth Subbannayya and Nazia Syed and Mustafa Ahmed Barbhuiya and R. Ananda Raja and Arivusudar Marimuthu and Nandini A. Sahasrabuddhe and Sneha M. Pinto and Srikanth Srinivas Manda and Santosh Renuse and Hosuru Chikkalingaiah Manju and Mohammed Abdul Lateef Zameer and Jyoti Sharma and Mariana Brait and Kotteazeth Srikumar and Juan Carlos S Roa and Manavalan Vijaya Kumar and Kariyanakatte Veeraiah Veerendra Kumar and Thottethodi Subrahmanya Keshava Prasad and Girija Ramaswamy and Rekha Vijay Kumar and Akhilesh Pandey and Harsha Gowda and Aditi Chatterjee},
  journal={Cancer biology & therapy},
  volume={16 2},
Gastric cancer is one of the most common gastrointestinal malignancies and is associated with poor prognosis. Exploring alterations in the proteomic landscape of gastric cancer is likely to provide potential biomarkers for early detection and molecules for targeted therapeutic intervention. Using iTRAQ-based quantitative proteomic analysis, we identified 22 proteins that were overexpressed and 17 proteins that were downregulated in gastric tumor tissues as compared to the adjacent normal tissue… CONTINUE READING
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