Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats.

@article{Vniant1994CalciumBV,
  title={Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats.},
  author={M M V{\'e}niant and Didier Heudes and J P Clozel and Patrick Bruneval and Jo{\"e}l M{\'e}nard},
  journal={Kidney international},
  year={1994},
  volume={46 2},
  pages={421-9}
}
ACE inhibitors have been shown to worsen the kidney damage occurring distal to a renal artery stenosis. To determine if this effect was due to the decrease of arterial pressure or to an inhibition of the formation of angiotensin, we compared the effects of equihypotensive doses of an angiotensin converting enzyme inhibitor (enalapril) and a long-acting calcium antagonist (Ro 40-5967) in 2K-1C rats. The rats were treated for five weeks with either enalapril, Ro 40-5967, or were left untreated. A… CONTINUE READING
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