Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.

@article{Nilius1988CalciumBO,
  title={Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.},
  author={Bernd Nilius},
  journal={The Journal of physiology},
  year={1988},
  volume={399},
  pages={537-58}
}
1. External Ca2+ block of Na+ channels was studied by a gigaohm-seal patch clamp technique in single cardiac ventricular cells from guinea-pig. Single-channel currents were recorded from cell-attached patches. 2. Increasing external Ca2+ concentrations in the patch pipette from 0.1 to 20 mM reduced the single-channel conductance of normal Na+ channels from 27 to 14 pS without causing flickering (obtained from linear regression, eight patches). 3. Exposed to external Ca2+ concentrations of 20 mM… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…