Calcium binding proteins in motoneurons at low and high risk for degeneration in ALS.

@article{Laslo2000CalciumBP,
  title={Calcium binding proteins in motoneurons at low and high risk for degeneration in ALS.},
  author={Peter Laslo and Janusz Lipski and Louise FB Nicholson and Gareth B Miles and Gregory D Funk},
  journal={Neuroreport},
  year={2000},
  volume={11 15},
  pages={3305-8}
}
Recent reports challenge the hypothesis that expression of calcium binding proteins contributes to the greater resistance of some motoneurons to degeneration in amyotrophic lateral sclerosis (ALS). We therefore re-examined, using immunohistochemistry, the expression of calbindin, calretinin and parvalbumin in vulnerable (hypoglossal, XII; and cervical spinal) and resistant (oculomotor, III) motoneurons of adult rats. Calbindin immunoreactivity was lacking in motor nuclei but strong in the… CONTINUE READING

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