• Corpus ID: 24393893

Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes.

  title={Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes.},
  author={Anand L. Misra and Salvatore J. Mul{\'e}},
  journal={Research communications in chemical pathology and pharmacology},
  volume={11 4},
  • A. MisraS. Mulé
  • Published 1975
  • Biology, Chemistry
  • Research communications in chemical pathology and pharmacology
Cocaine, benzoylecgonine, benzoylnorecgonine, norcocaine, ecgonine methyl ester but not ecgonine formed distinct molecular complexes with calcium chloride of the general formula [B. CaC12-2H20]. The particularly strong interaction observed with benzoylecgonine, benzoylnorecgonine and calcium may play a role in the potent stimulant activity of these 2 compounds observed in rats after intracisternal administration. 
2 Citations

Cocaine Effects on the Developing Central Nervous System: Behavioral, Psychopharmacological, and Neurochemical Studies

Subcutaneous administration of cocaine results in dose-dependent increases in brain and plasma cocaine in both dams and fetuses, and maternal plasma levels in the range of or above those observed in human cocaine users.

Fetal and maternal brain and plasma levels of cocaine and benzoylecgonine following chronic subcutaneous administration of cocaine during gestation in rats

The results of the present study suggest that the subcutaneous route may prove to be an appropriate means in rats for administering cocaine prenatally in investigations designed to assess potential neurobehavioral ramifications of gestational cocaine exposure.